Stone Mastic Asphalt Mixtures (SMA) are a kind of hot mix asphalt with Coarse aggregate skeleton and high percentage of bitumen and filler. Due to the high bitumen content and to prevent bitumen drain down and the maintenance of coarse aggregate, the use of additives Including fibers, polymer materials, nanomaterials, etc is needed. Therefore, the objective of this research is to investigate the effects of nanomaterials on the moisture sensitivity of SMA asphalt mixtures. In this research were used, silica aggregate, AC-60/70, two additive Evonik Dgosa in the amount of 0.15, 0.25 and 0.35%, and Zycotherm of 0.05, 0.1 and 0.15% of bitumen weight. AASHTO T283 (modified Lottman test), Resilient Modulus Ratio (RMR), dynamic creep and boiling water test were conducted to control moisture sensitivity and rutting performance. Results showed that Evonik up to 26% and Zycotherm (nanomaterial) up to 34% improve the performance of SMA asphalt mixtures against moisture.