In this paper the effect of Epoxy Resin polymer on moisture sensitivity of Asphalt mixtures containing Silica and limestone aggregates has been evaluated. Epoxy Resin without hardener  and Epoxy Resin curing with hardener ­­­­­ in 0, 1, 2, 3, 4, and 5 weight percentages for  Asphalt Binder modification have been applied. The method used for evaluating moisture sensitivity of Asphalt mixtures is Surface Free Energy method. In this method, with Surface Free Energy measurements of Asphalt Binder using Sessile Drop method and by using of the extracted values of Surface Free Energy of aggregates of valid reports, the energy parameters related to moisture sensitivity of Asphalt mixtures containing Asphalt Binder and aggregates compound, have been calculated and analyzed. At the end, base and modified Asphalt Binders with Epoxy Resin curing with hardener have been examined with FTIR test. The results show that the Epoxy Resin curing with hardener decreases moisture sensitivity of Asphalt mixtures containing Silica and limestone aggregates. Epoxy Resin without hardener does not have important effect on Asphalt mixtures containing limestone aggregates, but decreases moisture sensitivity of Asphalt mixtures containing Silica aggregates.