Surrogate safety measures make it possible to assess the level of risk and vulnerability of pedestrians. There are advantages to using these indicators: first, the independence of the accident statistics and some of its details and errors, and second, the possibility of examining risky interactions that did not lead to an accident, and third, in evaluating before and after safety policies and measures. In this research, practical surrogate safety measures related to pedestrian safety have been identified and the effective factors on these indicators have been determined. Innovations of the article includes the use of the Lane-based surrogate safety measure for pedestrians, as well as the combined examination of the Mid-block of pedestrian crossings in a street and at an intersection. Four Surrogate safety measures of Post Encroachment Time, Lane-based Post Encroachment Time, Gap Time and Time to Collision were calculated. Surrogate safety measures and extractable variables were extracted from the recorded videos in the streets of Isfahan and by linear fitting, significant variables for each surrogate safety measures as well as effective factors in increasing or decreasing each surrogate safety measures were identified. The results showed that the variables of Mid-block of pedestrian crossing, Conflict of a pedestrian with a car, presence of a SUV vehicle in the Conflict, gender of pedestrian, day light, Group crossing of pedestrian, direction of pedestrian movement, pedestrian velocity and car velocity are the most important Factors affecting safety of pedestrian and vehicle conflicts. It is important to pay attention to the mentioned variables in order to plan and predict appropriate facilities for pedestrians to cross the street.